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利用电子鼻进行呼气分析过敏性鼻炎与外源性哮喘的鉴别

来源: Silvano Dragonieri, Vitaliano N Quaranta, PierluigiCarratu  发布日期: 2019-01-15  点击次数: 36


To assess whether an e-nose could discriminate between subjects affected by allergic rhinitis with and without concomitant extrinsic asthma, as well as from healthy controls, in terms of exhaled VOC-profile. ...
 
Exhaled breath profiling by electronic nose enabled discrimination of allergic rhinitis and extrinsic asthma
1.
Silvano Dragonieri, Vitaliano N Quaranta, PierluigiCarratu, Teresa Ranieri & Onofrio Resta (2018) Exhaled breath profiling by electronic nose enabled discrimination of allergic rhinitis and extrinsic asthma, Biomarkers, DOI:10.1080/1354750X.2018.1508307
 
Abstract
Aim:To assess whether an e-nose could discriminate between subjects affected by allergic rhinitis with and without concomitant extrinsic asthma, as well as from healthy controls, in terms of exhaled VOC-profile.
 
Methods:Fourteen patients with Extrinsic Asthma and Allergic Rhinitis (AAR), 14 patients with Allergic Rhinit is without asthma (AR) and 14 healthy controls (HC) participated in a cross-sectional study. Exhaled breath was collected by a standardized method and sampled by an e-nose (Cyranose 320). Raw data were reduced by Principal component analysis and analyzed by canonical discriminant analysis. Cross-validation accuracy (CVA) and Receiver Operating Characteristic(ROC)-curves were calculated. External validation in newly recruited patients (7 AAR, 7AR and 7 HC) was tested using the previous training model.


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