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Cyranose 320电子鼻用于慢性阻塞性肺病(COPD)患者呼出气体日间重复性测量

来源: Maria Bofan1, Nadia Mores2, Marco Baron1, Malgorzata Dabrowska2, Salvatore Valente3, Maurizio Schmid1, Andrea Trov´e4, Silvia Conforto1, Gina Zini5  发布日期: 2019-04-09  访问量: 65


电子鼻(Cyranose 320)是一种人工传感器系统,通常由化学传感器阵列组成,用于检测挥发性化合物分布,在呼吸医学中有潜在的应用。我们在一天内和两天之间评估了由32个传感器制成的电子鼻在慢性阻塞性肺病(COPD)稳定患者中的重复性...
标签: Cyranose 320 电子鼻 慢性阻塞性肺病 COPD
 

Within-day and between-day repeatability of measurements with an electronic nose in patients with COPD

电子鼻用于慢性阻塞性肺病(COPD)患者呼出气体日间重复性测量
Maria Bofan1, Nadia Mores2, Marco Baron1, Malgorzata Dabrowska2,
Salvatore Valente3, Maurizio Schmid1, Andrea Trov´e4, Silvia Conforto1,
Gina Zini5, Paola Cattani6, Leonello Fuso3, Antonella Mautone3,
Chiara Mondino7, Gabriella Pagliari3, Tommaso D’Alessio1
and Paolo Montuschi3,8

Abstract
Electronic noses (Cyanose 320), artificial sensor systems generally consisting of chemical sensor arrays for the detection of volatile compound profiles, have potential applications in respiratory medicine. We assessed within-day and between-day repeatability of an e-nose made from 32 sensors in patients with stable chronic obstructive pulmonary disease (COPD). We also compared between-day repeatability of an e-nose, fraction of exhaled nitric oxide (FENO) and pulmonary function testing. Within-day and between-day repeatability for the e-nose was assessed in two breath samples collected 30 min and seven days apart, respectively. Repeatability was expressed as an intraclass correlation coefficient (ICC). All sensors had ICC above 0.5, a value that is considered acceptable for repeatability. Regarding within-day repeatability, ICC ranged from 0.75 to 0.84 (mean = 0.80 ± 0.004). Sensors 6 and 19 were the most reproducible sensors (both, ICC = 0.84). Regarding between-day repeatability, ICC ranged from 0.57 to 0.76 (mean = 0.68 ± 0.01). Sensor 19 was the most reproducible sensor (ICC = 0.76). Within-day e-nose repeatability was greater than between-day repeatability (P < 0.0001). Between-day repeatability of FENO (ICC = 0.91) and spirometry (ICC range = 0.94–0.98) was greater than that of e-nose (mean ICC = 0.68). In patients with stable COPD, the e-nose used in this study has acceptable within-day and between-day repeatability which varies between different sensors.

电子鼻(Cyranose 320)是一种人工传感器系统,通常由化学传感器阵列组成,用于检测挥发性化合物分布,在呼吸医学中有潜在的应用。我们在一天内和两天之间评估了由32个传感器制成的电子鼻在慢性阻塞性肺病(COPD)稳定患者中的重复性。我们还比较了电子鼻的白天重复性、呼出的一氧化氮(Feno)分数和肺功能测试。在一天之内和两天之间,分别在30分钟和7天间隔采集的两个呼吸样本中评估电子鼻的可重复性。重复性用组内相关系数(ICC)表示。所有传感器的ICC都高于0.5,这一数值被认为是可接受的重复性。关于日间重复性,ICC范围为0.75至0.84(平均值=0.80±0.004)。传感器6和19是可重复性最高的传感器(两者,ICC=0.84)。关于日间重复性,ICC范围为0.57至0.76(平均值=0.68±0.01)。传感器19是可重复性最高的传感器(ICC=0.76)。在一天内,电子鼻的重复性大于两天之间的重复性(p<0.0001)。FENO(ICC=0.91)和肺活量测定(ICC范围=0.94-0.98)的日间重复性高于E鼻(平均ICC=0.68)。对于稳定型慢性阻塞性肺病患者,本研究中使用的电子鼻在一天内和两天之间具有可接受的重复性,不同传感器之间的重复性不同。


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