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Cyranose 320电子鼻用于慢性阻塞性肺病(COPD)患者呼出气体日间重复性测量

来源: Maria Bofan1, Nadia Mores2, Marco Baron1, Malgorzata Dabrowska2, Salvatore Valente3, Maurizio Schmid1, Andrea Trov´e4, Silvia Conforto1, Gina Zini5  发布日期: 2019-04-09  点击次数: 18


Electronic noses (Cyanose 320), artificial sensor systems generally consisting of chemical sensor arrays for the detection of volatile compound profiles, have potential applications in respiratory medicine. We assessed within-day and between-day repeatabi...
 

Within-day and between-day repeatability of measurements with an electronic nose in patients with COPD
Maria Bofan1, Nadia Mores2, Marco Baron1, Malgorzata Dabrowska2,
Salvatore Valente3, Maurizio Schmid1, Andrea Trov´e4, Silvia Conforto1,
Gina Zini5, Paola Cattani6, Leonello Fuso3, Antonella Mautone3,
Chiara Mondino7, Gabriella Pagliari3, Tommaso D’Alessio1
and Paolo Montuschi3,8

Abstract
Electronic noses (Cyanose 320), artificial sensor systems generally consisting of chemical sensor arrays for the detection of volatile compound profiles, have potential applications in respiratory medicine. We assessed within-day and between-day repeatability of an e-nose made from 32 sensors in patients with stable chronic obstructive pulmonary disease (COPD). We also compared between-day repeatability of an e-nose, fraction of exhaled nitric oxide (FENO) and pulmonary function testing. Within-day and between-day repeatability for the e-nose was assessed in two breath samples collected 30 min and seven days apart, respectively. Repeatability was expressed as an intraclass correlation coefficient (ICC). All sensors had ICC above 0.5, a value that is considered acceptable for repeatability. Regarding within-day repeatability, ICC ranged from 0.75 to 0.84 (mean = 0.80 ± 0.004). Sensors 6 and 19 were the most reproducible sensors (both, ICC = 0.84). Regarding between-day repeatability, ICC ranged from 0.57 to 0.76 (mean = 0.68 ± 0.01). Sensor 19 was the most reproducible sensor (ICC = 0.76). Within-day e-nose repeatability was greater than between-day repeatability (P < 0.0001). Between-day repeatability of FENO (ICC = 0.91) and spirometry (ICC range = 0.94–0.98) was greater than that of e-nose (mean ICC = 0.68). In patients with stable COPD, the e-nose used in this study has acceptable within-day and between-day repeatability which varies between different sensors.


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