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基于电子鼻技术呼吸气味印记诊断非肿瘤性慢性疾病研究

来源: Raffaele Antonelli Incalzi, Antonio De Vincentis, Claudio Pedone  发布日期: 2019-06-10  访问量: 101


最初专注于确定所选挥发性有机化合物(VOC)的研究目前正致力于通过电子鼻全面评估呼吸疾病的呼吸模式(呼吸图-bps)的研究。与对照组相比,年轻哮喘患者具有独特的血压特征,但血压仅随疾病严重程度的轻微变化,目前尚不清楚相同的结论是否适用于其他哮喘人群(老年人、晚发病等)...
标签: cyranose 电子鼻 呼出气体 非肿瘤 慢性疾病
 

Breathprinting-Based Diagnosis, Selected Case Study: Nonneoplastic Chronic Diseases

基于电子鼻技术呼吸气味印记诊断非肿瘤性慢性疾病研究
Raffaele Antonelli Incalzi, Antonio De Vincentis, Claudio Pedone
DEPARTMENT OF GERIATRICS, CAMPUS BIO-MEDICO UNIVERSITY, ROME, ITALY


1 Respiratory Diseases
1.1 Summary
Research initially focusing on the identification of selected volatile organic compounds (VOCs) is currently bending toward studies comprehensively assessing the breath patterns (breath-prints - BPs) of respiratory diseases through e-noses. Distinctive BPs characterize young asthmatic patients versus controls, but BP only minimally changes with disease severity, and it’s unclear whether the same conclusion applies to other asthma populations (elderly, late onset, etc.). In COPD, BP provides highly reproducible findings that strongly correlate with spirometric parameters. BP clearly distinguishes COPD patients from controls, and changes depending upon whether inhaled therapy includes a steroid. In OSAS, BP can capture both early and late metabolic effects of nocturnal ventilation. Overall, available evidence suggests BP may conveniently help in diagnosing selected respiratory diseases (to confirm asthma or to exclude COPD or OSAS), to determine severity (COPD), or to track responses to therapies (COPD and OSAS). Furthermore, BP could qualify as a diagnostic surrogate in elderly, mainly disabled and multimorbid subjects, who are not able to perform spirometry. However, these conclusions stem from relatively few data, the majority of which were obtained in selected populations, free from the confounding effects of comorbidities and therapies. Analogously, results in infectious diseases and interstitial lung disease, albeit promising, still lack the desirable consistency. Large cooperative efforts are needed to overcome these limitations, and disclose the full diagnostic potential of the e-nose in respiratory diseases.

最初专注于确定所选挥发性有机化合物(VOC)的研究目前正致力于通过电子鼻全面评估呼吸疾病的呼吸模式(呼吸图-bps)的研究。与对照组相比,年轻哮喘患者具有独特的血压特征,但血压仅随疾病严重程度的轻微变化,目前尚不清楚相同的结论是否适用于其他哮喘人群(老年人、晚发病等)。在慢性阻塞性肺病中,血压提供了高度可重复的发现,与肺计量参数密切相关。血压清楚地将慢性阻塞性肺病患者与对照组区分开来,并根据吸入疗法是否包括类固醇而改变。在OSAS中,血压可以捕捉夜间通气的早期和晚期代谢效应。总的来说,现有证据表明,BP可以方便地帮助诊断选定的呼吸系统疾病(确认哮喘或排除慢性阻塞性肺病或OSAS),确定严重程度(慢性阻塞性肺病),或跟踪对治疗的反应(慢性阻塞性肺病和OSAS)。此外,对于不能进行肺活量测定的老年人,主要是残疾和多病态受试者,BP可以作为诊断替代物。然而,这些结论来源于相对较少的数据,其中大多数数据是在选定的人群中获得的,没有共病和治疗的混杂效应。类似地,导致传染病和间质性肺病,虽然有希望,但仍然缺乏理想的一致性。为了克服这些局限性,并充分揭示电子鼻在呼吸道疾病中的诊断潜力,需要进行大量的合作。

 


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