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当前位置: 首页 > 技术文献 > 应用文献 > 电子鼻分析挥发性有机物用于膀胱癌无创检测的初步研究
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电子鼻分析挥发性有机物用于膀胱癌无创检测的初步研究

来源: HENDRIK HEERS, JOSEF MAXIMILIAN GUT et al  发布日期: 2019-08-12  访问量: 200


膀胱镜检查,膀胱肿瘤的标准诊断,是不舒服,侵入性、昂贵的。可用的尿液标记系统都缺乏准确性。测量尿液中的挥发性有机化合物(VOC)是一种很有前途的选择。该试点研究评估了用电子鼻鉴别膀胱癌患者尿液和健康对照的可行性。...
标签: cyranose 320、电子鼻、无创检测、膀胱癌、挥发性有机物
 

Non-invasive Detection of Bladder Tumors Through Volatile Organic Compounds: A Pilot Study with an Electronic Nose

电子鼻分析挥发性有机物用于膀胱癌无创检测的初步研究
HENDRIK HEERS1, JOSEF MAXIMILIAN GUT1, AXEL HEGELE1, RAINER HOFMANN1,
TOBIAS BOESELT2, AKIRA HATTESOHL2 and ANDREAS REMBERT KOCZULLA2
1Department of Urology and Paediatric Urology,Philipps-Universität Marburg, Marburg, Germany;
2Department of Pulmonology, Philipps-Universität Marburg, Marburg, Germany

Abstract.

Background/Aim: Cystoscopy, the standard diagnostic for bladder tumors, is uncomfortable, invasive, and expensive. The available urine-based marker systems all
lack accuracy. Measuring volatile organic compounds (VOCs) from urine is a promising alternative. This pilot study evaluates the feasibility of discriminating bladder cancer patients’ urine from healthy controls with an electronic nose.

膀胱镜检查,膀胱肿瘤的标准诊断,是不舒服,侵入性、昂贵的。可用的尿液标记系统都缺乏准确性。测量尿液中的挥发性有机化合物(VOC)是一种很有前途的选择。该试点研究评估了用电子鼻鉴别膀胱癌患者尿液和健康对照的可行性。

Materials and Methods: Headspace measurements of urine samples of 30 patients with confirmed transitional cell carcinoma (TCC) and 30 healthy controls were performed with Cyranose 320 calculating Mahalanobis distance and linear discriminant analysis. Histology reports following TUR-BT were correlated with urine findings.

采用Cyranose 320计算Mahalanobis距离和线性判别分析,对30例确诊的移行细胞癌(TCC)和30例健康对照的尿样进行顶空测量。TUR-BT后的组织学报告与尿液检查结果相关。

Results: After storage at –20°C, Cyranose correctly detected 28/30 already confirmed TCC samples and 26/30 healthy controls (p<0.01), sensitivity 93.3%, specificity 86.7%. Storage at –80°C led to similar results: 28/30 tumor samples and 28/30 control samples were correctly allocated; sensitivity and specificity both 93.3%.

在-20°C储存后,Cyranose正确检测到28/30已证实的TCC样本和26/30健康对照(p <0.01),敏感性为93.3%,特异性为86.7%。在-80℃下储存导致类似的结果:28/30肿瘤样品和28/30对照样品被正确分配; 敏感性和特异性均为93.3%。

Conclusion: VOC detection is a promising tool to detect bladder tumors. Further research will test against possible confounders like bacteriuria.

VOC检测是检测膀胱肿瘤的有效工具。进一步的研究将测试可能的混杂因素,如菌尿。


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