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验证新型经皮动脉气体递质传感器 (Tags™) 系统在测量人体经皮硫化氢中的作用


来源: B.T. Matheson et al   发布日期: 2022-04-26  访问量: 114


一种新的非侵入性系统已被开发用于测量人体上下肢经皮释放的硫化氢(H2S)。经皮动脉气体传递素传感器(TAGS)™ ) 之前的研究表明,它可以检测到与生理测量(1-100 ppb)相关的1-100 ppb之间的低水平H2S...
标签: 硫化氢,生物传感器,透皮,无创,TAGS
 

Validation of the Novel Transdermal Arterial Gasotransmitter Sensor (Tags™) System in Measuring Transdermal Hydrogen Sulfide in Human Subjects

验证新型经皮动脉气体递质传感器 (Tags™) 系统在测量人体经皮硫化氢中的作用

B.T. Matheson, R.B. Osofsky, D.M. Friedrichsen, B.J. Brooks, R. Shekarriz, R.M. Clark, N.L. Kanagy

Abstract

A novel non-invasive system has been developed to measure transdermally emitted hydrogen sulfide (H2S) from the upper and lower limbs of human subjects. The transdermal arterial gasotransmitter sensor (TAGS ™ ) has previously been shown to detect low levels of H 2 S ranging between 1-100 ppb considered relevant for physiological measurements (1-100 ppb). 1 This study was designed to compare its measurement precision to a commercially available chemiluminescent device, the H2S-selective Ecotech Serinus 55 TRS ™ . Although TAGS™ does in-situ and real-time sampling, the comparative studies in this paper collected gases emitted from the arm of 10 human subjects between the ages of 27-59. Three replicate samples of each individual were collected for 30 minutes in a sealed 10L Tedlar ® bag to allow readings from the same sample by both devices. Readings from the TAGS ™ system correlated strongly with the values obtained from the Serinus ™ device, with a correlation coefficient of R 2 = 0.8691, p < 0.0001. These results indicate that TAGS ™ measures transdermal H 2 S specifically and accurately. Because vascular endothelial cells are a known source of H2S, TAGS ™ measurements may provide a non-invasive means of detecting endothelial dysfunction, the underlying cause of peripheral artery disease (PAD) and microvascular disease. TAGS™ has potential clinical applications such as monitoring skin vascular perfusion in individuals with suspected vascular disease.

一种新的非侵入性系统已被开发用于测量人体上下肢经皮释放的硫化氢(H2S)。经皮动脉气体传递素传感器(TAGS)™ ) 之前的研究表明,它可以检测到与生理测量(1-100 ppb)相关的1-100 ppb之间的低水平H2S。1本研究旨在将其测量精度与商用化学发光装置H2S选择性Ecotech Serinus 55 TRS™进行比较 . 虽然TAGS™ 通过现场和实时采样,本文中的对比研究收集了10名年龄在27-59岁之间的受试者手臂发出的气体。在一个密封的10L Tedlar®袋中收集每个人的三个重复样本30分钟,以允许两台设备读取相同样本的读数。TAGS™ 系统与从Serinus获得的值密切相关装置,相关系数r2=0.8691,p<0.0001。这些结果表明TAGS™ 具体准确地测量经皮H2S。因为血管内皮细胞是已知的H2S来源,TAGS™ 测量可以提供一种非侵入性的方法来检测内皮功能障碍,这是外周动脉疾病(PAD)和微血管疾病的根本原因。TAGS™ 具有潜在的临床应用,如监测疑似血管疾病患者的皮肤血管灌注

 

Keywords: hydrogen sulfide, biosensor, transdermal, non-invasive, TAGS

关键词:硫化氢,生物传感器,透皮,无创,TAGS

 

 

 


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