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呼吸节律不影响电子鼻分析的呼出挥发性有机化合物分布


来源: Silvano Dragonieri et al  发布日期: 2022-09-08  访问量: 136


评估电子鼻分析时,呼吸节律的变化是否反映呼出VOC曲线的变化
标签: 呼吸节律、呼气VOC、电子鼻、气味指纹
 

Breathing rhythm does not influence exhaled volatile organic compound profile analyzed by an electronic nose

Silvano Dragonieri, Vitaliano Nicola Quaranta, Enrico Buonamico, Fabrizio Diaferia, Giovanna Elisiana Carpagnano
European Respiratory Journal 2021 58: PA1153; DOI: 10.1183/13993003.congress-2021.PA1153

Abstract

Background: E-noses are innovative tools for exhaled Volatile Organic Compound (VOC)-analysis which have shown their potential in several diseases. Before obtaining a full validation of these instruments in clinical settings, a number of methodological issues still have to be established.

Aim of the Study: To assess whether variations of breathing rhythm may reflect changes in terms of exhaled VOC-profile when analyzed by an e-nose.

背景:电子鼻是呼出挥发性有机化合物(VOC)分析的创新工具,已显示其在多种疾病中的潜力。在临床环境中对这些器进行全面验证之前,仍需确定一些方法学问题。

研究目的:评估电子鼻分析时,呼吸节律的变化是否反映呼出VOC曲线的变化。

Methods: 

We enrolled 20 normal subjects and randomly collected their exhaled breath at three different breathing rhythms: a) normal rhythm (RR between 12-18/min), b) fast rhythm (RR>25/min) and c) slow rhythm (RR<10/min). Exhaled breath was collected by a previously validated method and analyzed by an e-nose (Cyranose 320).

我们招募了20名正常受试者,随机收集他们在三种不同呼吸节律下的呼气:a)正常节律(RR在12-18/min之间)、b)快节律(RR25/min以上)和c)慢节律(rr10/min以下)。通过先前验证的方法收集呼出的呼吸,并通过电子鼻(Cyranose 320)进行分析.

Results: 

By Principal Component Analysis, no significant variations of the exhaled VOC-profile were shown among the three breathing rhythms. Subsequent Linear Discriminant analysis confirmed the above findings with a cross validated accuracy of 45% (p=ns).

通过主成分分析,三种呼吸节律之间呼出的VOC曲线没有显著变化。随后的线性判别分析证实了上述发现,交叉验证的准确率为45%(p=ns)。

Conclusions:

 Exhaled VOC-s profile may not be influenced by variations of breathing rhythm.

呼出的VOC-s曲线可能不受呼吸节律变化的影响。

 

 


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