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细胞代谢重编程控制果蝇糖食欲


来源: Zita Carvalho-Santos et al  发布日期: 2021-04-26  访问量: 71


细胞代谢重编程是细胞重组代谢以促进细胞增殖和生长的重要机制。这一过程主要是在肿瘤发生的背景下研究的,但对其与非病理过程的相关性以及对整个动物生理学的影响知之甚少。在这里,我们表明,在果蝇雌性生殖细胞代谢重编程影响动物的营养偏好...
标签: 果蝇摄食,细胞代谢编程
 

Cellular metabolic reprogramming controls sugar appetite in Drosophila

Zita Carvalho-Santos, Rita Cardoso-Figueiredo, Ana Paula Elias, Ibrahim Tastekin, Célia Baltazar & Carlos Ribeiro

Abstract

Cellular metabolic reprogramming is an important mechanism by which cells rewire their metabolism to promote proliferation and cell growth. This process has been mostly studied in the context of tumorigenesis, but less is known about its relevance for nonpathological processes and how it affects whole-animal physiology. Here, we show that metabolic reprogramming in Drosophila female germline cells affects nutrient preferences of animals. Egg production depends on the upregulation of the activity of the pentose phosphate pathway in the germline, which also specifically increases the animal’s appetite for sugar, the key nutrient fuelling this metabolic pathway. We provide functional evidence that the germline alters sugar appetite by regulating the expression of the fat-body-secreted satiety factor Fit. Our findings demonstrate that the cellular metabolic program of a small set of cells is able to increase the animal’s preference for specific nutrients through inter-organ communication to promote specific metabolic and cellular outcomes

细胞代谢重编程是细胞重组代谢以促进细胞增殖和生长的重要机制。这一过程主要是在肿瘤发生的背景下研究的,但对其与非病理过程的相关性以及对整个动物生理学的影响知之甚少。在这里,我们表明,在果蝇雌性生殖细胞代谢重编程影响动物的营养偏好。卵子的产生依赖于生殖系中磷酸戊糖途径的活性上调,这也特别增加了动物对糖的食欲,而糖是促进这一代谢途径的关键营养物质。我们提供了种系通过调节脂肪体分泌的饱食因子Fit的表达来改变糖食欲的功能证据。我们的研究结果表明,一小部分细胞的细胞代谢程序能够通过器官间的交流增加动物对特定营养素的偏好,从而促进特定的代谢和细胞结果。

 

原文链接:https://www.nature.com/articles/s42255-020-0266-x


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