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结合TLC和IMS分析2-3-4-氧代苯基氨基甲酸衍生物的位置异构体


来源: Zuzana Štiffelová et al  发布日期: 2021-10-14  访问量: 9


烷氧基苯基氨基甲酸的一些衍生物的位置异构体的分离。这些化合物属于具有局部麻醉剂活性的药物。这些低挥发性的化合物通过薄层色谱法(TLC)和离子迁移谱法(IMS)进行分析,使用二极管激光解吸法将样品引入IMS。这种结合的方法允许对化合物进行鉴定...
标签: 烷氧基苯基氨基甲酸,离子迁移谱法,薄层色谱法,位置异构体
 

Analysis of positional isomers of 2-3-4-alkoxyphenylcarbamic acid derivatives by a combination of TLC and IMS

结合TLC和IMS分析2-3-4-氧代苯基氨基甲酸衍生物的位置异构体
Zuzana Štiffelováa,Ladislav Moravskýb,Bartosz Michalczukb,c,Jozef Čižmárika,Štefan Matejčíkb,Fils Andriamaintya

aDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, Odbojárov 10, 83232 Bratislava, Slovakia
bDepartment of Experimental Physics, Comenius University, Mlynská dolina F2, 84248 Bratislava, Slovakia
cSiedlce University of Natural Sciences and Humanities, Faculty of Exact and Natural Sciences, Siedlce, Poland
Received 25 November 2020, Revised 13 September 2021, Accepted 29 September 2021, Available online 4 October 2021.

 

Highlights
•The differences in the ion mobility spectra of isomers arise from differences in the geometry of the molecules and ions.
•The combination of TLC with IMS is a promising tool for analysing positional isomers of compounds of very low volatility.

-异构体的离子迁移率光谱的差异来自于分子和离子的几何形状的不同。
-TLC与IMS的结合是分析挥发性极低的化合物的位置异构体的一个很有前途的工具。

Abstract

In this study, we have demonstrated a separation of positional isomers of some derivatives of alkoxyphenylcarbamic acid. These compounds belong to drugs with local anesthetics activity. The low volatility compounds were analysed by a Thin Layer Chromatography (TLC) and Ion Mobility Spectrometry (IMS) using diode laser desorption for sample introduction to IMS. This combined approach allowed the identification of compounds. Also, we have carried out IMS studies of all compounds and determined their ion mobilities The ion mobilities were increasing with the geometry change from position ortho to para of alkoxy chain, which is in agreement with their different collision cross section (CCS).

在这项研究中,我们证明了烷氧基苯基氨基甲酸的一些衍生物的位置异构体的分离。这些化合物属于具有局部麻醉剂活性的药物。这些低挥发性的化合物通过薄层色谱法(TLC)和离子迁移谱法(IMS)进行分析,使用二极管激光解吸法将样品引入IMS。这种结合的方法允许对化合物进行鉴定。此外,我们还对所有的化合物进行了IMS研究,并确定了它们的离子迁移率。离子迁移率随着烷氧基链从正向到反向的几何变化而增加,这与它们不同的碰撞截面(CCS)一致。

Keywords
Alkoxyphenylcarbamic acid,Ion Mobility Spectrometry,Thin Layer Chromatography,Positional isomers

烷氧基苯基氨基甲酸,离子迁移谱法,薄层色谱法,位置异构体


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