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器官几何的性别


来源: Laura Blackie et al   发布日期: 2024-06-12  访问量: 32


器官在身体中有一个独特但经常被忽视的空间排列,我们认为,器官的形状及其与相邻器官的距离是有逻辑的。在这里,通过使用许多果蝇的体积扫描,我们开发了量化器官形状、位置和个体间变异的三维特征的方法
标签: 器官、几何、性别、果蝇
 

The sex of organ geometry

器官几何的性别

Laura Blackie, Pedro Gaspar, Salem Mosleh, Oleh Lushchak, Lingjin Kong, Yuhong Jin, Agata P. Zielinska, Boxuan Cao, Alessandro Mineo, Bryon Silva, Tomotsune Ameku, Shu En Lim, Yanlan Mao, Lucía Prieto-Godino, Todd Schoborg, Marta Varela, L. Mahadevan & Irene Miguel-Aliaga

Abstract

Organs have a distinctive yet often overlooked spatial arrangement in the body1,2,3,4,5. We propose that there is a logic to the shape of an organ and its proximity to its neighbours. Here, by using volumetric scans of many Drosophila melanogaster flies, we develop methods to quantify three-dimensional features of organ shape, position and interindividual variability. We find that both the shapes of organs and their relative arrangement are consistent yet differ between the sexes, and identify unexpected interorgan adjacencies and left–right organ asymmetries. Focusing on the intestine, which traverses the entire body, we investigate how sex differences in three-dimensional organ geometry arise. The configuration of the adult intestine is only partially determined by physical constraints imposed by adjacent organs; its sex-specific shape is actively maintained by mechanochemical crosstalk between gut muscles and vascular-like trachea. Indeed, sex-biased expression of a muscle-derived fibroblast growth factor-like ligand renders trachea sexually dimorphic. In turn, tracheal branches hold gut loops together into a male or female shape, with physiological consequences. Interorgan geometry represents a previously unrecognized level of biological complexity which might enable or confine communication across organs and could help explain sex or species differences in organ function.

器官在身体中有一个独特但经常被忽视的空间排列1,2,3,4,5。我们认为,器官的形状及其与相邻器官的距离是有逻辑的。在这里,通过使用许多果蝇的体积扫描,我们开发了量化器官形状、位置和个体间变异的三维特征的方法。我们发现,器官的形状及其相对排列在性别之间是一致但不同的,并发现了意想不到的器官间邻接和左右器官不对称。以贯穿全身的肠道为重点,我们研究了三维器官几何结构中的性别差异是如何产生的。成人肠道的结构仅部分由相邻器官施加的物理约束决定;它的性别特异性形状是由肠道肌肉和血管样气管之间的机械化学串扰积极维持的。事实上,肌肉来源的成纤维细胞生长因子样配体的性别偏向性表达使气管呈现性别二型。反过来,气管分支将肠环固定在一起,形成雄性或雌性的形状,产生生理后果。器官间几何形状代表了一种以前未被认识到的生物复杂性水平,这可能会使器官之间的交流成为可能或限制交流,并有助于解释器官功能的性别或物种差异。

 

文章来源: The sex of organ geometry | Nature


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